Akira Houjou and Chiaki Asami are childhood friends who have experienced hell and lived to tell about it. They arrive in Japan to attend school, and soon witness the corruption and apathy of the country's population. Enraged, Akira and Asami vow to create a new Japan; a sanctuary with a new form of politics, devoid of corruption, where people are empowered to participate in the politics and future of their country. To accomplish this, Houjou and Asami aim to conquer Japan through two dramatically different routes: the Japanese Diet and the Yakuza. Decided by a game of rock-paper-scissors, Houjou ventures to seize control of the underworld while Asami pursues the position of Prime Minister.

Sanctuary is a dark, political thriller that tells the story of these two friends as they attempt to change Japan from the inside out and create their sanctuary.